Interference with the Host Haemostatic System by Schistosomes

Interference with the Host Haemostatic System by Schistosomes

Schistosomes, parasitic flatworms that cause the tropical disease schistosomiasis, are still a threat. They are responsible for 200 million infections worldwide and an estimated 280,000 deaths annually in sub-Saharan Africa alone. The adult parasites reside as pairs in the mesenteric or perivesicular veins of their human host, where they can survive for up to 30 years. The parasite is a potenti...

Tracking the Odysseys of Juvenile Schistosomes to Understand Host Interactions

The prospects confronting a ‘‘new-born’’ schistosome cercaria are formidable. That some of these microscopic helminths successfully negotiate the tortuous route from snail to human vasculature is a truly remarkable feature of adaptive biology. After escaping the birth pore of its parental sporocyst, a cercaria (at least we infer from studies of other digeneans [1]) swims and crawls through the ...

Host Determinants of Reinfection with Schistosomes in Humans: A Systematic Review and Meta-analysis

BACKGROUND Schistosomiasis is still a major public health burden in the tropics and subtropics. Although there is an effective chemotherapy (Praziquantel) for this disease, reinfection occurs rapidly after mass drug administration (MDA). Because the entire population do not get reinfected at the same rate, it is possible that host factors may play a dominant role in determining resistance or su...

INTERFERENCE CANCELLATION SYSTEM by Saad

Interference of Host Innate Immune Response by Hepatitis E Virus

Title of Document: INTERFERENCE OF HOST INNATE IMMUNE RESPONSE BY HEPATITIS E